Recent publications
Simultaneous disruption of PRC2 and enhancer function underlies histone H3.3-K27M oncogenic activity in human hindbrain neural stem cells
Brien GL, Bressan RB, Monger C, Gannon D, Lagan E, Doherty AM, Healy E, Neikes H, Fitzpatrick DJ, Deevy O, Grant V, Marqués-Torrejón MA, Alfazema N, Pollard SM, Bracken AP
Nat Genet. 2021 Aug;53(8):1221-1232.doi: 10.1038/s41588-021-00897-w
Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer
Bracken AP, Brien GL, Verrijzer CP
Genes Dev. 2019 Aug 1;33(15-16):936-959. doi: 10.1101/gad.326066.119
Targeting chromatin complexes in fusion protein-driven malignancies
Brien GL, Stegmaier K, Armstrong SA
Nat Rev Cancer. 2019 May;19(5):255-269. doi: 10.1038/s41568-019-0132-x
Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma
Brien GL, Remillard D, Shi J, Hemming ML, Chabon J, Wynne K, Dillon ET, Cagney G, Van Mierlo G, Baltissen MP, Vermeulen M, Qi J, Fröhling S, Gray NS, Bradner JE, Vakoc CR, Armstrong SA
Elife. 2018 Nov 15;7:e41305. doi: 10.7554/eLife.41305
Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
Remillard D, Buckley DL, Paulk J, Brien GL, Sonnett M, Seo HS, Dastjerdi S, Wühr M, Dhe-Paganon S, Armstrong SA, Bradner JE
Angew Chem Int Ed Engl. 2017 May 15;56(21):5738-5743. doi: 10.1002/anie.201611281
